DHEA is claimed to prevent or slow the aging process; promote weight loss; prevent heart disease; prevent or alleviate Alzheimer's disease; combat AIDS, lupus and some cancers.
Studies on weight loss, certain cancers, and immunity are still in the early research stage, with work primarily completed on animals. Studies on aging, lupus, and as a postmenopausal replacement therapy have been completed on only small numbers of individuals. At this time, not enough evidence exits to support the claims.
Liver cancer occurred in rats that had been given DHEA. Supplementation can lead to increased insulin resistance, the growth of unwanted hair and a drop in HDL (good) cholesterol levels.